MOF phosphorylation by ATM regulates 53BP1-mediated DSB repair pathway choice

Cell cycle phase is a critical determinant of the choice between DNA damage repair by non-homologous end joining (NHEJ) or homologous recombination (HR). Here we report that DSBs induce ATM-dependent MOF (a histone H4 acetyl-transferase) phosphorylation (p-T392-MOF) and that phosphorylated MOF co-lo...

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Pubblicato in:Cell Rep
Autori principali: Gupta, Arun, Hunt, Clayton R., Hegdec, Muralidhar L., Chakraborty, Sharmistha, Udayakumar, Durga, Horikoshi, Nobuo, Singh1, Mayank, Ramnarain, Deepti B., Hittelman, Walter N., Namjoshi, Sarita, Asaithamby, Aroumougame, Hazra, Tapas K., Ludwig, Thomas, Pandita, Raj K., Tyler, Jessica K., Pandita, Tej K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4300955/
https://ncbi.nlm.nih.gov/pubmed/24953651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.044
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