T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice

Ataxia telangiectasia patients develop lymphoid malignancies of both B- and T-cell origin. Similarly, ataxia telangiectasia mutated (Atm)-deficient mice exhibit severe defects in T-cell maturation and eventually develop thymomas. The function of ATM is known to be influenced by the mammalian ortholo...

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Bibliographische Detailangaben
Hauptverfasser: Gupta, Arun, Hunt, Clayton R., Pandita, Raj K., Pae, Juhee, Komal, K., Singh, Mayank, Shay, Jerry W., Kumar, Rakesh, Ariizumi, Kiyoshi, Horikoshi, Nobuo, Hittelman, Walter N., Guha, Chandan, Ludwig, Thomas, Pandita, Tej K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
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Original Manuscript
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630520/
https://ncbi.nlm.nih.gov/pubmed/23386701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/ges080
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