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Smac mimetics combined with innate immune stimuli create the perfect cytokine storm to kill tumor cells

A dual immunotherapy approach employing small-molecule inhibitors of apoptosis (IAP) protein antagonists in combination with innate immune stimuli has proven to be highly synergistic and effective in animal tumor models. This strategy overcomes many of the limitations of either single agent therapy...

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Autori principali: Beug, Shawn T, LaCasse, Eric C, Korneluk, Robert G
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063156/
https://ncbi.nlm.nih.gov/pubmed/25050221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.28541
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