SMG1 and NIK regulate apoptosis induced by Smac mimetic compounds

Smac mimetic compounds (SMCs) are experimental small molecules that induce tumour necrosis factor alpha (TNFα)-dependent cancer cell death by targeting the inhibitor of apoptosis proteins. However, many cancer cell lines are resistant to SMC-mediated apoptosis despite the presence of TNFα. To add in...

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Detalhes bibliográficos
Main Authors: Cheung, H H, St Jean, M, Beug, S T, Lejmi-Mrad, R, LaCasse, E, Baird, S D, Stojdl, D F, Screaton, R A, Korneluk, R G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122057/
https://ncbi.nlm.nih.gov/pubmed/21490678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.25
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