Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model

Rhabdomyosarcoma (RMS), a neoplasm characterized by undifferentiated myoblasts, is the most common soft tissue tumour in children. Therapeutic resistance is common in RMS and is often caused by acquired defects in the cellular apoptotic program. Smac mimetic compounds (SMCs) are a novel class of inh...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Dobson, Christine C, Naing, Thet, Beug, Shawn T, Faye, Mame D, Chabot, Janelle, St-Jean, Martin, Walker, Danielle E, LaCasse, Eric C, Stojdl, David F, Korneluk, Robert G, Holcik, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2016
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356898/
https://ncbi.nlm.nih.gov/pubmed/27966453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13849
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