Structure-Guided Rescaffolding of Selective Antagonists of BCL-X(L)

[Image: see text] Because of the promise of BCL-2 antagonists in combating chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL), interest in additional selective antagonists of antiapoptotic proteins has grown. Beginning with a series of selective, potent BCL-X(L) antagonists containi...

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Autores principales: Koehler, Michael F. T., Bergeron, Philippe, Choo, Edna F., Lau, Kevin, Ndubaku, Chudi, Dudley, Danette, Gibbons, Paul, Sleebs, Brad E., Rye, Carl S., Nikolakopoulos, George, Bui, Chinh, Kulasegaram, Sanji, Kersten, Wilhelmus J. A., Smith, Brian J., Czabotar, Peter E., Colman, Peter M., Huang, David C. S., Baell, Jonathan B., Watson, Keith G., Hasvold, Lisa, Tao, Zhi-Fu, Wang, Le, Souers, Andrew J., Elmore, Steven W., Flygare, John A., Fairbrother, Wayne J., Lessene, Guillaume
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2014
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060937/
https://ncbi.nlm.nih.gov/pubmed/24944740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500030p
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