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Control of catalytic efficiency by a coevolving network of catalytic and noncatalytic residues

The active sites of enzymes consist of residues necessary for catalysis and structurally important noncatalytic residues that together maintain the architecture and function of the active site. Examples of evolutionary interactions between catalytic and noncatalytic residues have been difficult to d...

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Bibliografiske detaljer
Main Authors: McMurrough, Thomas A., Dickson, Russell J., Thibert, Stephanie M. F., Gloor, Gregory B., Edgell, David R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060692/
https://ncbi.nlm.nih.gov/pubmed/24912189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322352111
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