Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease

Susceptibility to chronic beryllium disease (CBD) is linked to certain HLA-DP molecules, including HLA-DP2. To elucidate the molecular basis of this association, we exposed mice transgenic (Tg) for HLA-DP2 to beryllium oxide (BeO) via oropharyngeal aspiration. As opposed to WT mice, BeO-exposed HLA-...

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Библиографические подробности
Главные авторы: Mack, Douglas G., Falta, Michael T., McKee, Amy S., Martin, Allison K., Simonian, Philip L., Crawford, Frances, Gordon, Terry, Mercer, Robert R., Hoover, Mark D., Marrack, Philippa, Kappler, John W., Tuder, Rubin M., Fontenot, Andrew P.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2014
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060652/
https://ncbi.nlm.nih.gov/pubmed/24912188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1408048111
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