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The dynamics of SecM-induced translational stalling

SecM is an E. coli secretion monitor capable of stalling translation on the prokaryotic ribosome without co-factors. Biochemical and structural studies have demonstrated that the SecM nascent chain interacts with the 50S subunit exit tunnel to inhibit peptide bond formation. However, the timescales...

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Detalhes bibliográficos
Main Authors: Tsai, Albert, Kornberg, Guy, Johansson, Magnus, Chen, Jin, Puglisi, Joseph D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059775/
https://ncbi.nlm.nih.gov/pubmed/24836001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.04.033
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