Conditional disruption of interactions between Gα(i2) and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury

BACKGROUND: Regulator of G protein signaling (RGS) proteins suppress G protein coupled receptor signaling by catalyzing the hydrolysis of Gα-bound guanine nucleotide triphosphate. Transgenic mice in which RGS-mediated regulation of Gα(i2) is lost (RGS insensitive Gα(i2)(G184S)) exhibit beneficial (p...

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Autores principales: Parra, Sergio, Huang, Xinyan, Charbeneau, Raelene A, Wade, Susan M, Kaur, Kuljeet, Rorabaugh, Boyd R, Neubig, Richard R
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059092/
https://ncbi.nlm.nih.gov/pubmed/24899231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2050-6511-15-29
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