Gα(i2)-mediated protection from ischaemic injury is modulated by endogenous RGS proteins in the mouse heart

AIMS: Regulator of G protein signalling (RGS) proteins act as molecular ‘off switches’ that terminate G protein signalling by catalyzing the hydrolysis of Gα-bound GTP to GDP. Many different Gα(i)-coupled receptors have been implicated in the cardioprotective effects of ischaemic preconditioning. Ho...

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Bibliographic Details
Main Authors: Waterson, Rachael E., Thompson, Corbin G., Mabe, Nathaniel W., Kaur, Kuljeet, Talbot, Jeffery N., Neubig, Richard R., Rorabaugh, Boyd R.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2011
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3112020/
https://ncbi.nlm.nih.gov/pubmed/21349876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr054
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