RGS inhibition at Gα(i2) selectively potentiates 5-HT1A–mediated antidepressant effects

Elevating serotonin (5-HT) levels with selective serotonin reuptake inhibitors (SSRIs) is the most widely used treatment for depression. However, current therapies are ineffective, have delayed benefit, or cause side effects in many patients. Here, we define a mechanism downstream of 5-HT1A receptor...

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Detalhes bibliográficos
Main Authors: Talbot, Jeffery N., Jutkiewicz, Emily M., Graves, Steven M., Clemans, Crystal F., Nicol, Melanie R., Mortensen, Richard M., Huang, Xinyan, Neubig, Richard R., Traynor, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890727/
https://ncbi.nlm.nih.gov/pubmed/20534514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000003107
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