Mu-Opioid Receptor Coupling to Gα(o) Plays an Important Role in Opioid Antinociception

Opioid analgesics elicit their effects via activation of the mu-opioid receptor (MOR), a G protein-coupled receptor known to interact with Gα(i/o)-type G proteins. Work in vitro has suggested that MOR couples preferentially to the abundant brain Gα(i/o) isoform, Gα(o). However, studies in vivo evalu...

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Bibliografische gegevens
Hoofdauteurs: Lamberts, Jennifer T, Jutkiewicz, Emily M, Mortensen, Richard M, Traynor, John R
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2011
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158321/
https://ncbi.nlm.nih.gov/pubmed/21654736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.91
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