Targeting peripheral blood pro-inflammatory cytotoxic lymphocytes by inhibiting CD137 expression: novel potential treatment for COPD

BACKGROUND: We have shown that chronic obstructive pulmonary disease (COPD) is associated with increased production of pro-inflammatory cytokines and the cytotoxic mediator, granzyme B by peripheral blood steroid resistant CD28nullCD137 + CD8+ T cells and granzyme B by NKT-like and NK cells. We hypo...

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Hlavní autoři: Hodge, Greg, Holmes, Mark, Jersmann, Hubertus, Reynolds, Paul N, Hodge, Sandra
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059030/
https://ncbi.nlm.nih.gov/pubmed/24885856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2466-14-85
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