Lymphocyte senescence in COPD is associated with loss of glucocorticoid receptor expression by pro-inflammatory/cytotoxic lymphocytes

BACKGROUND: Glucocorticoid (GC) resistance is a major barrier in COPD treatment. We have shown increased expression of the drug efflux pump, Pgp1 in cytotoxic/pro-inflammatory lymphocytes in COPD. Loss of lymphocyte co-stimulatory molecule CD28 (lymphocyte senescence) was associated with a further i...

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Bibliographische Detailangaben
Veröffentlicht in:Respir Res
Hauptverfasser: Hodge, Greg, Jersmann, Hubertus, Tran, Hai B, Holmes, Mark, Reynolds, Paul N, Hodge, Sandra
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301939/
https://ncbi.nlm.nih.gov/pubmed/25573300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-014-0161-7
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