The drug efflux pump Pgp1 in pro-inflammatory lymphocytes is a target for novel treatment strategies in COPD

BACKGROUND: Pro-inflammatory/cytotoxic T cells (IFNγ, TNFα, granzyme B+) are increased in the peripheral circulation in COPD. NKT-like and NK cells are effector lymphocytes that we have also shown to be major sources of pro-inflammatory cytokines and granzymes. P-glycoprotein 1 (Pgp1) is a transmemb...

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Main Authors: Hodge, Greg, Holmes, Mark, Jersmann, Hubertus, Reynolds, Paul N, Hodge, Sandra
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3681551/
https://ncbi.nlm.nih.gov/pubmed/23731729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-63
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