Lymphocyte senescence in COPD is associated with decreased sirtuin 1 expression in steroid resistant pro-inflammatory lymphocytes

BACKGROUND: The class III NAD-dependent histone deacetylase (HDAC) sirtuin 1 (SIRT1) is an important regulator of senescence, aging, and inflammation. SIRT1de-acetylates chromatin histones, thereby silencing inflammatory gene transcription. We have reported increased steroid-resistant senescent pro-...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Ther Adv Respir Dis
Main Authors: Hodge, Greg, Tran, Hai B., Reynolds, Paul N., Jersmann, Hubertus, Hodge, Sandra
Format: Artigo
Jezik:Inglês
Izdano: SAGE Publications 2020
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7153179/
https://ncbi.nlm.nih.gov/pubmed/32270742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753466620905280
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