Lymphocyte senescence in COPD is associated with decreased histone deacetylase 2 expression by pro-inflammatory lymphocytes

BACKGROUND: Histone acetyltransferases (HAT) and histone deacetylases (HDAC) are enzymes that upregulate and down-regulate pro-inflammatory gene transcription respectively. HDAC2 is required by corticosteroids to switch off activated inflammatory genes and is reduced in lung macrophages in COPD. We...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Hodge, Greg, Jersmann, Hubertus, Tran, Hai B., Roscioli, Eugene, Holmes, Mark, Reynolds, Paul N., Hodge, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4619495/
https://ncbi.nlm.nih.gov/pubmed/26498345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-015-0287-2
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