Hyperactivation of Alk induces neonatal lethality in knock-in Alk(F1178L) mice

The ALK (Anaplastic Lymphoma Kinase) gene encodes a tyrosine kinase receptor preferentially expressed in the central and peripheral nervous systems. A syndromic presentation associating congenital neuroblastoma with severe encephalopathy and an abnormal shape of the brainstem has been described in p...

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Autori principali: Lopez-Delisle, Lucille, Pierre-Eugène, Cécile, Bloch-Gallego, Evelyne, Birling, Marie-Christine, Duband, Jean-Loup, Durand, Estelle, Bourgeois, Thomas, Matrot, Boris, Sorg, Tania, Huerre, Michel, Meziane, Hamid, Roux, Michel J., Champy, Marie-France, Gallego, Jorge, Delattre, Olivier, Janoueix-Lerosey, Isabelle
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058038/
https://ncbi.nlm.nih.gov/pubmed/24811761
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