Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

The anaplastic lymphoma kinase (ALK) gene is overexpressed, mutated or amplified in most neuroblastoma (NB), a pediatric neural crest-derived embryonal tumor. The two most frequent mutations, ALK-F1174L and ALK-R1275Q, contribute to NB tumorigenesis in mouse models, and cooperate with MYCN in the on...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Montavon, Gisèle, Jauquier, Nicolas, Coulon, Aurélie, Peuchmaur, Michel, Flahaut, Marjorie, Bourloud, Katia Balmas, Yan, Pu, Delattre, Olivier, Sommer, Lukas, Joseph, Jean-Marc, Janoueix-Lerosey, Isabelle, Gross, Nicole, Mühlethaler-Mottet, Annick
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147337/
https://ncbi.nlm.nih.gov/pubmed/24947326
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars