Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

The anaplastic lymphoma kinase (ALK) gene is overexpressed, mutated or amplified in most neuroblastoma (NB), a pediatric neural crest-derived embryonal tumor. The two most frequent mutations, ALK-F1174L and ALK-R1275Q, contribute to NB tumorigenesis in mouse models, and cooperate with MYCN in the on...

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Detalhes bibliográficos
Main Authors: Montavon, Gisèle, Jauquier, Nicolas, Coulon, Aurélie, Peuchmaur, Michel, Flahaut, Marjorie, Bourloud, Katia Balmas, Yan, Pu, Delattre, Olivier, Sommer, Lukas, Joseph, Jean-Marc, Janoueix-Lerosey, Isabelle, Gross, Nicole, Mühlethaler-Mottet, Annick
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147337/
https://ncbi.nlm.nih.gov/pubmed/24947326
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