Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio

BACKGROUND: Neuroblastoma (NB) is the second most common solid childhood tumour, an aggressive disease for which new therapeutic strategies are strongly needed. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in most tumour cells, but not in normal tiss...

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Bibliographic Details
Main Authors: Mühlethaler-Mottet, Annick, Flahaut, Marjorie, Bourloud, Katia Balmas, Auderset, Katya, Meier, Roland, Joseph, Jean-Marc, Gross, Nicole
Format: Artigo
Language:Inglês
Published: BioMed Central 2006
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1569857/
https://ncbi.nlm.nih.gov/pubmed/16930472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-214
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