Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia

Neuroblastoma (NB) is an embryonal malignancy derived from the abnormal differentiation of the sympathetic nervous system. The Anaplastic Lymphoma Kinase (ALK) gene is frequently altered in NB, through copy number alterations and activating mutations, and represents a predisposition in NB-genesis wh...

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書目詳細資料
發表在:Front Oncol
Main Authors: Vivancos Stalin, Lucie, Gualandi, Marco, Schulte, Johannes Hubertus, Renella, Raffaele, Shakhova, Olga, Mühlethaler-Mottet, Annick
格式: Artigo
語言:Inglês
出版: Frontiers Media S.A. 2019
主題:
Oncology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477091/
https://ncbi.nlm.nih.gov/pubmed/31058082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00275
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