Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia

Neuroblastoma (NB) is an embryonal malignancy derived from the abnormal differentiation of the sympathetic nervous system. The Anaplastic Lymphoma Kinase (ALK) gene is frequently altered in NB, through copy number alterations and activating mutations, and represents a predisposition in NB-genesis wh...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Vivancos Stalin, Lucie, Gualandi, Marco, Schulte, Johannes Hubertus, Renella, Raffaele, Shakhova, Olga, Mühlethaler-Mottet, Annick
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477091/
https://ncbi.nlm.nih.gov/pubmed/31058082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00275
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