Expression of the Neuroblastoma-Associated ALK-F1174L Activating Mutation During Embryogenesis Impairs the Differentiation of Neural Crest Progenitors in Sympathetic Ganglia

Neuroblastoma (NB) is an embryonal malignancy derived from the abnormal differentiation of the sympathetic nervous system. The Anaplastic Lymphoma Kinase (ALK) gene is frequently altered in NB, through copy number alterations and activating mutations, and represents a predisposition in NB-genesis wh...

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Bibliografische gegevens
Gepubliceerd in:Front Oncol
Hoofdauteurs: Vivancos Stalin, Lucie, Gualandi, Marco, Schulte, Johannes Hubertus, Renella, Raffaele, Shakhova, Olga, Mühlethaler-Mottet, Annick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2019
Onderwerpen:
Oncology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477091/
https://ncbi.nlm.nih.gov/pubmed/31058082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00275
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