Development and Evaluation of Small Peptidomimetic Ligands to Protease-Activated Receptor-2 (PAR(2)) through the Use of Lipid Tethering

Protease-activated receptor-2 (PAR(2)) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR(2) with in vitro physiological and Ca(2+) signaling assays to d...

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Bibliographic Details
Main Authors: Boitano, Scott, Hoffman, Justin, Tillu, Dipti V., Asiedu, Marina N., Zhang, Zhenyu, Sherwood, Cara L., Wang, Yan, Dong, Xinzhong, Price, Theodore J., Vagner, Josef
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057235/
https://ncbi.nlm.nih.gov/pubmed/24927179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099140
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