Hypercontractility of Intestinal Longitudinal Smooth Muscle Induced by Cytokines Is Mediated by the Nuclear Factor-κB/AMP-Activated Kinase/Myosin Light Chain Kinase Pathway

Recent studies have identified AMP-activated kinase (AMPK) as a target of Ca(2+)/calmodulin-dependent kinase kinase (CaMKKβ) and a negative regulator of myosin light-chain (MLC) kinase (MLCK). The present study examined whether a change in expression or activity of AMPK is responsible for hypercontr...

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Detalhes bibliográficos
Main Authors: Nalli, Ancy D., Kumar, Divya P., Mahavadi, Sunila, Al-Shboul, Othman, Alkahtani, Reem, Kuemmerle, John F., Grider, John R., Murthy, Karnam S.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4056271/
https://ncbi.nlm.nih.gov/pubmed/24769544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.212522
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