Mismatch repair in Escherichia coli enhances instability of (CTG)n triplet repeats from human hereditary diseases.

Long CTG triplet repeats which are associated with several human hereditary neuromuscular disease genes are stabilized in ColE1-derived plasmids in Escherichia coli containing mutations in the methyl-directed mismatch repair genes (mutS, mutL, or mutH). When plasmids containing (CTG)180 were grown f...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Jaworski, A, Rosche, W A, Gellibolian, R, Kang, S, Shimizu, M, Bowater, R P, Sinden, R R, Wells, R D
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40562/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479928/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11019
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