Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells

The interaction with brain endothelial cells is central to the pathogenicity of Neisseria meningitidis infections. Here, we show that N. meningitidis causes transient activation of acid sphingomyelinase (ASM) followed by ceramide release in brain endothelial cells. In response to N. meningitidis inf...

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Autors principals: Simonis, Alexander, Hebling, Sabrina, Gulbins, Erich, Schneider-Schaulies, Sibylle, Schubert-Unkmeir, Alexandra
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055770/
https://ncbi.nlm.nih.gov/pubmed/24945304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004160
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