Differential Activation of Acid Sphingomyelinase and Ceramide Release Determines Invasiveness of Neisseria meningitidis into Brain Endothelial Cells

The interaction with brain endothelial cells is central to the pathogenicity of Neisseria meningitidis infections. Here, we show that N. meningitidis causes transient activation of acid sphingomyelinase (ASM) followed by ceramide release in brain endothelial cells. In response to N. meningitidis inf...

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Hauptverfasser: Simonis, Alexander, Hebling, Sabrina, Gulbins, Erich, Schneider-Schaulies, Sibylle, Schubert-Unkmeir, Alexandra
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4055770/
https://ncbi.nlm.nih.gov/pubmed/24945304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004160
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