Neisseria meningitidis Type IV Pili Trigger Ca(2+)-Dependent Lysosomal Trafficking of the Acid Sphingomyelinase To Enhance Surface Ceramide Levels

Acid sphingomyelinase (ASM) is a lipid hydrolase that converts sphingomyelin to ceramide and that can be activated by various cellular stress mechanisms, including bacterial pathogens. Vesicle transportation or trafficking of ASM from the lysosomal compartment to the cell membrane is a prerequisite...

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Bibliografische gegevens
Gepubliceerd in:Infect Immun
Hoofdauteurs: Peters, Simon, Schlegel, Jan, Becam, Jérôme, Avota, Elita, Sauer, Markus, Schubert-Unkmeir, Alexandra
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2019
Onderwerpen:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652772/
https://ncbi.nlm.nih.gov/pubmed/31160362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00410-19
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