Neisseria meningitidis Type IV Pili Trigger Ca(2+)-Dependent Lysosomal Trafficking of the Acid Sphingomyelinase To Enhance Surface Ceramide Levels

Acid sphingomyelinase (ASM) is a lipid hydrolase that converts sphingomyelin to ceramide and that can be activated by various cellular stress mechanisms, including bacterial pathogens. Vesicle transportation or trafficking of ASM from the lysosomal compartment to the cell membrane is a prerequisite...

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Bibliografske podrobnosti
izdano v:Infect Immun
Main Authors: Peters, Simon, Schlegel, Jan, Becam, Jérôme, Avota, Elita, Sauer, Markus, Schubert-Unkmeir, Alexandra
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6652772/
https://ncbi.nlm.nih.gov/pubmed/31160362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00410-19
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