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Neisseria meningitidis Type IV Pili Trigger Ca(2+)-Dependent Lysosomal Trafficking of the Acid Sphingomyelinase To Enhance Surface Ceramide Levels
Acid sphingomyelinase (ASM) is a lipid hydrolase that converts sphingomyelin to ceramide and that can be activated by various cellular stress mechanisms, including bacterial pathogens. Vesicle transportation or trafficking of ASM from the lysosomal compartment to the cell membrane is a prerequisite...
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| Veröffentlicht in: | Infect Immun |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6652772/ https://ncbi.nlm.nih.gov/pubmed/31160362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00410-19 |
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