A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike Protein

Prophylactic and therapeutic strategies are urgently needed to combat infections caused by the newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we have developed a neutralizing monoclonal antibody (MAb), designated Mersmab1, which potently blocks MERS-CoV entry into human...

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Detalhes bibliográficos
Main Authors: Du, Lanying, Zhao, Guangyu, Yang, Yang, Qiu, Hongjie, Wang, Lili, Kou, Zhihua, Tao, Xinrong, Yu, Hong, Sun, Shihui, Tseng, Chien-Te K., Jiang, Shibo, Li, Fang, Zhou, Yusen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054355/
https://ncbi.nlm.nih.gov/pubmed/24719424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00433-14
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