Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants

Middle East respiratory syndrome coronavirus (MERS-CoV) binds to cellular receptor dipeptidyl peptidase 4 (DPP4) via the spike (S) protein receptor-binding domain (RBD). The RBD contains critical neutralizing epitopes and serves as an important vaccine target. Since RBD mutations occur in different...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Tai, Wanbo, Wang, Yufei, Fett, Craig A., Zhao, Guangyu, Li, Fang, Perlman, Stanley, Jiang, Shibo, Zhou, Yusen, Du, Lanying
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5165220/
https://ncbi.nlm.nih.gov/pubmed/27795425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01651-16
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