Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape

Middle East respiratory syndrome coronavirus (MERS-CoV) causes a highly lethal pulmonary infection with ∼35% mortality. The potential for a future pandemic originating from animal reservoirs or health care-associated events is a major public health concern. There are no vaccines or therapeutic agent...

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Vydáno v:J Virol
Hlavní autoři: Wang, Lingshu, Shi, Wei, Chappell, James D., Joyce, M. Gordon, Zhang, Yi, Kanekiyo, Masaru, Becker, Michelle M., van Doremalen, Neeltje, Fischer, Robert, Wang, Nianshuang, Corbett, Kizzmekia S., Choe, Misook, Mason, Rosemarie D., Van Galen, Joseph G., Zhou, Tongqing, Saunders, Kevin O., Tatti, Kathleen M., Haynes, Lia M., Kwong, Peter D., Modjarrad, Kayvon, Kong, Wing-Pui, McLellan, Jason S., Denison, Mark R., Munster, Vincent J., Mascola, John R., Graham, Barney S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923077/
https://ncbi.nlm.nih.gov/pubmed/29514901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02002-17
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