Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor

A high-throughput screening campaign was conducted to interrogate a 380,000+ small-molecule library for novel D2 dopamine receptor modulators using a calcium mobilization assay. Active agonist compounds from the primary screen were examined for orthogonal D2 dopamine receptor signaling activities in...

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Detalles Bibliográficos
Main Authors: Free, R. Benjamin, Chun, Lani S., Moritz, Amy E., Miller, Brittney N., Doyle, Trevor B., Conroy, Jennie L., Padron, Adrian, Meade, Julie A., Xiao, Jingbo, Hu, Xin, Dulcey, Andrés E., Han, Yang, Duan, Lihua, Titus, Steve, Bryant-Genevier, Melanie, Barnaeva, Elena, Ferrer, Marc, Javitch, Jonathan A., Beuming, Thijs, Shi, Lei, Southall, Noel T., Marugan, Juan J., Sibley, David R.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2014
Assuntos:
Accelerated Communication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054005/
https://ncbi.nlm.nih.gov/pubmed/24755247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.090563
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