Hepatocellular Exposure of Troglitazone Metabolites in Rat Sandwich-Cultured Hepatocytes Lacking Bcrp and Mrp2: Interplay between Formation and Excretion

Inhibition of bile acid transport by troglitazone (TGZ) and its major metabolite, TGZ sulfate (TS), may lead to hepatocellular accumulation of toxic bile acids; TS accumulation and hepatotoxicity may be associated with impaired TS biliary excretion. This study evaluated the impact of impaired transp...

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Bibliographic Details
Main Authors: Yang, Kyunghee, Brouwer, Kim L. R.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053994/
https://ncbi.nlm.nih.gov/pubmed/24799397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.114.057190
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