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Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.

Growth factor-binding protein 2 (Grb2) is an adaptor protein that links tyrosine kinases to Ras. BCR-ABL is a tyrosine kinase oncoprotein that is implicated in the pathogenesis of Philadelphia chromosome (Ph1)-positive leukemias. Grb2 forms a complex with BCR-ABL and the nucleotide exchange factor S...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Gishizky, M L, Cortez, D, Pendergast, A M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40536/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479904/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.10889
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