Mutant forms of growth factor-binding protein-2 reverse BCR-ABL-induced transformation.
Growth factor-binding protein 2 (Grb2) is an adaptor protein that links tyrosine kinases to Ras. BCR-ABL is a tyrosine kinase oncoprotein that is implicated in the pathogenesis of Philadelphia chromosome (Ph1)-positive leukemias. Grb2 forms a complex with BCR-ABL and the nucleotide exchange factor S...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40536/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479904/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.10889 |
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