The Bcr-Abl leukemia oncogene activates Jun kinase and requires Jun for transformation.

The leukemogenic tyrosine kinase fusion protein Bcr-Abl activates a Ras-dependent pathway required for transformation. To examine subsequent signal transduction events we measured the effect of Bcr-Abl on two mitogen-activated protein kinase (MAPK) cascades--the extracellular signal-regulated kinase...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Raitano, A B, Halpern, J R, Hambuch, T M, Sawyers, C L
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1995
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40479/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524841/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11746
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