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Aortic Valve Calcification is Mediated by a Differential Response of Aortic Valve Interstitial Cells to Inflammation

BACKGROUND: While calcific aortic stenosis is common, calcification of the other three heart valves is not. The aortic valve interstitial cell (VIC) has been implicated in the pathogenesis of aortic stenosis. Pro-inflammatory stimulation of aortic VICs induces an osteogenic and inflammatory phenotyp...

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Detalhes bibliográficos
Main Authors: Venardos, Neil, Nadlonek, Nicole A., Zhan, Qiong, Weyant, Michael J., Reece, T. Brett, Meng, Xianzhong, Fullerton, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4053510/
https://ncbi.nlm.nih.gov/pubmed/24746950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2014.03.051
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