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Enhanced Prostacyclin Formation and Wnt Signaling in Sclerostin Deficient Osteocytes and Bone
We show that prostacyclin production is increased in bone and osteocytes from sclerostin (Sost) knockout mice which have greatly increased bone mass. The addition of prostacyclin or a prostacyclin analog to bone forming osteoblasts enhances differentiation and matrix mineralization of osteoblasts. T...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4052706/ https://ncbi.nlm.nih.gov/pubmed/24780398 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.04.092 |
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