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Alterations in Vitamin D Metabolite, Parathyroid Hormone and Fibroblast Growth Factor-23 Concentrations in Sclerostin-Deficient Mice Permit the Maintenance of a High Bone Mass
Humans with mutations of the sclerostin (Sost) gene, and knockout animals in which the Sost gene has been experimentally deleted, exhibit an increase in bone mass. We review the mechanisms by which Sost knockout mice are able to accrete increased amount of calcium and phosphorus required for the mai...
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| Pubblicato in: | J Steroid Biochem Mol Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4361263/ https://ncbi.nlm.nih.gov/pubmed/25446885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2014.11.021 |
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