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Alterations in Vitamin D Metabolite, Parathyroid Hormone and Fibroblast Growth Factor-23 Concentrations in Sclerostin-Deficient Mice Permit the Maintenance of a High Bone Mass
Humans with mutations of the sclerostin (Sost) gene, and knockout animals in which the Sost gene has been experimentally deleted, exhibit an increase in bone mass. We review the mechanisms by which Sost knockout mice are able to accrete increased amount of calcium and phosphorus required for the mai...
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| Publicado no: | J Steroid Biochem Mol Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4361263/ https://ncbi.nlm.nih.gov/pubmed/25446885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2014.11.021 |
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