Sclerostin Deficient Mice Rapidly Heal Bone Defects by Activating β-Catenin and Increasing Intramembranous Ossification

We investigated the influence of the osteocyte protein, sclerostin, on fracture healing by examining the dynamics and mechanisms of repair of single-cortex, stabilized femoral defects in sclerostin knockout (Sost(−/−); KO) and sclerostin wild-type (Sost(+/+); WT) mice. Fourteen days following genera...

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Main Authors: McGee-Lawrence, Meghan E., Ryan, Zachary C., Carpio, Lomeli R., Kakar, Sanjeev, Westendorf, Jennifer J., Kumar, Rajiv
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876417/
https://ncbi.nlm.nih.gov/pubmed/24211207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.10.155
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