Probing the Transmembrane Structure and Dynamics of Microsomal NADPH-cytochrome P450 oxidoreductase by Solid-State NMR

NADPH-cytochrome P450 oxidoreductase (CYPOR) is an essential redox partner of the cytochrome P450 (cyt P450) superfamily of metabolic enzymes. In the endoplasmic reticulum of liver cells, such enzymes metabolize ∼75% of the pharmaceuticals in use today. It is known that the transmembrane domain of C...

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Detalhes bibliográficos
Main Authors: Huang, Rui, Yamamoto, Kazutoshi, Zhang, Meng, Popovych, Nataliya, Hung, Ivan, Im, Sang-Choul, Gan, Zhehong, Waskell, Lucy, Ramamoorthy, Ayyalusamy
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Membranes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052271/
https://ncbi.nlm.nih.gov/pubmed/24853741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.03.051
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