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A silencer-proximal intronic region is required for sustained CD4 expression in post-selection thymocytes
It has been proposed that differential kinetics of CD4/CD8 co-receptors regulate fate choice of selected thymocytes. Sustained signals by interaction between MHC class II and TCR/CD4 is required for commitment to the CD4 helper lineage. While prematurely terminated MHC-TCR/CD4 interaction in transge...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4052224/ https://ncbi.nlm.nih.gov/pubmed/24729613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302374 |
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