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A silencer-proximal intronic region is required for sustained CD4 expression in post-selection thymocytes

It has been proposed that differential kinetics of CD4/CD8 co-receptors regulate fate choice of selected thymocytes. Sustained signals by interaction between MHC class II and TCR/CD4 is required for commitment to the CD4 helper lineage. While prematurely terminated MHC-TCR/CD4 interaction in transge...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Henson, David M., Chou, Chun, Sakurai, Nagisa, Egawa, Takeshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052224/
https://ncbi.nlm.nih.gov/pubmed/24729613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1302374
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