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Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene
CD4 coreceptor expression is negatively regulated through activity of the Cd4 silencer in CD4(–)CD8(–) double-negative (DN) thymocytes and CD8(+) cytotoxic lineage T cells. Whereas Cd4 silencing is reversed during transition from DN to CD4(+)CD8(+) double-positive stages, it is maintained through he...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3169121/ https://ncbi.nlm.nih.gov/pubmed/21873191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112293108 |
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