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Transcription factor AP4 modulates reversible and epigenetic silencing of the Cd4 gene

CD4 coreceptor expression is negatively regulated through activity of the Cd4 silencer in CD4(–)CD8(–) double-negative (DN) thymocytes and CD8(+) cytotoxic lineage T cells. Whereas Cd4 silencing is reversed during transition from DN to CD4(+)CD8(+) double-positive stages, it is maintained through he...

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Autors principals: Egawa, Takeshi, Littman, Dan R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3169121/
https://ncbi.nlm.nih.gov/pubmed/21873191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112293108
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