Predicting Protein Aggregation during Storage in Lyophilized Solids Using Solid State Amide Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)

[Image: see text] Solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS) was used to assess the conformation of myoglobin (Mb) in lyophilized formulations, and the results correlated with the extent of aggregation during storage. Mb was colyophilized with sucrose (...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Moorthy, Balakrishnan S., Schultz, Steven G., Kim, Sherry G., Topp, Elizabeth M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2014
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051254/
https://ncbi.nlm.nih.gov/pubmed/24816133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500005v
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk