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Characterizing Protein Structure, Dynamics and Conformation in Lyophilized Solids
The long-term stability of protein therapeutics in the solid-state depends on the preservation of native structure during lyophilization and in the lyophilized powder. Proteins can reversibly or irreversibly unfold upon lyophilization, acquiring conformations susceptible to degradation during storag...
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| Publicado no: | Curr Pharm Des |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4671836/ https://ncbi.nlm.nih.gov/pubmed/26446463 |
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