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Predicting Protein Aggregation during Storage in Lyophilized Solids Using Solid State Amide Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)
[Image: see text] Solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS) was used to assess the conformation of myoglobin (Mb) in lyophilized formulations, and the results correlated with the extent of aggregation during storage. Mb was colyophilized with sucrose (...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Chemical
Society
2014
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4051254/ https://ncbi.nlm.nih.gov/pubmed/24816133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500005v |
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