Predicting Protein Aggregation during Storage in Lyophilized Solids Using Solid State Amide Hydrogen/Deuterium Exchange with Mass Spectrometric Analysis (ssHDX-MS)

[Image: see text] Solid state amide hydrogen/deuterium exchange with mass spectrometric analysis (ssHDX-MS) was used to assess the conformation of myoglobin (Mb) in lyophilized formulations, and the results correlated with the extent of aggregation during storage. Mb was colyophilized with sucrose (...

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Главные авторы: Moorthy, Balakrishnan S., Schultz, Steven G., Kim, Sherry G., Topp, Elizabeth M.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4051254/
https://ncbi.nlm.nih.gov/pubmed/24816133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp500005v
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